Prognostic Significance of Ki-67 Antigen Immunostaining (MIB-1 Monoclonal Antibody) in Ovarian Cancer
نویسندگان
چکیده
منابع مشابه
Prognostic significance of Ki-67 antigen immunostaining (MIB-1 monoclonal antibody) in ovarian cancer.
OBJECTIVE To assess the potential usefulness of Ki-67 antigen expression as a predictor of outcome in ovarian cancer through the analysis of MIB-1 monoclonal antibody reactivity. METHODS Cell proliferation and clinicopathologic variables were assessed in 26 patients with primary epithelial ovarian cancer who had undergone exploratory laparotomy. The expression of primary tumor proliferation r...
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Nearly every pathologist that practices in a community hospital setting struggles with the accurate and reproducible identification of HPV effect and dysplasia in the female genital tract, and recognizes the fact that in certain situations these conditions can be very difficult to distinguish from reactive changes. Last month in the ProPath "Focus on Immunohistochemistry", we reviewed the poten...
متن کاملMeasurement of Ki-67 antigen in 159 pituitary adenomas using the MIB-1 monoclonal antibody.
Pituitary adenomas sometimes show rapid growth and recurrence, and about one third invade the structures surrounding the sella turcica. In an attempt to determine aggressive behavior at an early stage, we used the MIB-1 antibody to identify the Ki-67 antigen. The present study was designed to evaluate pituitary adenomatous tissue in terms of secretion and proliferation and to correlate the Ki-6...
متن کاملPROGNOSTIC SIGNIFICANCE OF MIB-1 (Ki-67) EXPRESSION IN PROSTATE CANCER AND MATCHED LYMPH NODE METASTASES
MIB-1 is a marker expressed only in proliferating cells. The aim of this study was to evaluate MIB-1 (Ki-67) labeling index in primary prostate cancer and matched nodal metastases for its prognostic value. Forty radical prostatectomy specimens from 2008 to 2009 were randomly selected for this study. Tumor blocks were immunostained using the monoclonal antibody MIB-1 (Dakorp. Denmark). MIB-1 exp...
متن کاملDetermination of Ki-67 defined growth fraction by monoclonal antibody MIB-1 in formalin-fixed, paraffin-embedded prostatic cancer tissues.
The applicability of MIB-1, a monoclonal antibody directed against the Ki-67 antigen, was studied in the PC-82 and LNCaP prostatic tumor models at various levels of proliferative activity. Statistically significant correlations were found in LNCaP cultures between Ki-67 and MIB-1 scores (r = 0.84, P < 0.001), and in PC-82 tumors between MIB-1 scores and paraffin tissue Ki-67 (pKi-67) (r = 0.90,...
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ژورنال
عنوان ژورنال: Journal of Nippon Medical School
سال: 2004
ISSN: 1345-4676,1347-3409
DOI: 10.1272/jnms.71.384